Comment: This systematic review is suggestive, but not conclusive. The BP reduction with treatment was very small, with the systolic blood pressure being lowered only by 3.6 mmHg compared to patients given placebo. It appears there may be an effect of antihypertensive medications that go beyond their effect on blood pressure. Without knowing the individual agents used, these possible effects are difficult to determine. Should the goal be to put people with grade 1 hypertension on antihypertensive agent, but not have a target BP? After all, this review found a systolic BP reduction of only 3.6 mmHg, making it hard to imaging that the BP reduction was the primary factor in reducing stroke and early death. NCBINCBI Logo Skip to main content Skip to navigation Resources How To About NCBI Accesskeys ehbufefjmxorMy NCBISign Out PubMed US National Library of Medicine National Institutes of Health Search databaseSearch term Search AdvancedHelp Result Filters For (retrieved Dec, 2014).
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