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This study found that rehydration of patients with an ischemic stroke and a BUN/Cr ratio of >= 15 was associated with a decreased risk of stroke in evolution. The rehydration group received a normal saline bolus of 300 to 500 cc then 40 to 80 ml/hr x 72H. The second group did not receive a normal saline bolus and IVF rate was much less day #1 and was 0 ml/hr days 2 and 3. Comment: Traditionally, a BUN/Cr ratio of > 20 suggests dehydration or pre-renal disease; a ratio of 10 to 20 is considered normal or post-renal disease; a ratio of less than 10 suggests intra-renal disease (renal damage decreases BUN reabsorption). These authors used a cutoff of 15, and gently rehydrated patients with a BUN/Cr ratio above this level. http://bit.ly/1lzZOmh Am J Emerg Med. 2014 Apr 4.    (retrieved Apr, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.