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This meta-analysis found no cardiovascular benefit of dietary polyunsaturated fatty acids over dietary saturated fatty acids. Dietary trans fatty acids however appeared to increase risk. Comment: Statistically, there was no clear benefit of dietary polyunsaturated fatty acids over saturated or monounsaturated fatty acids. Dietary supplementation with polyunsaturated fatty acids also did not appear to be of benefit, although supplementation with omega 6 polyunsaturated fatty acid supplements might possibly (but not definitely) be better than linoleic fatty acid supplements. Ann Intern Med. 2014 Mar 18;160(6):398-406    (retrieved Apr, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.