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This study found that pregabalin appears as effective as pramipexole in treating restless legs syndrome. However, iatrogenic worsening was much less with pregabalin compared to 0.5 mg of pramipexole. Comment: This study raises the question of whether or not gabapentin, a similar compound to pregabalin, would have similar positive effects upon restless legs syndrome, but with fewer adverse effects compared to pramipexole. N Engl J Med. 2014 Feb 13;370(7):621-31.    (retrieved Mar, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.