In a population of 100,000 there are 1000 people who have a disease. Every year, 500 new people get the disease, and 500 are cured. What is the incidence of disease?

A. 500 per 100,000 people

B. 1500 per 100,000 per year

C. 1000 per 100,000 people

D. 500 per 100,000 per year

E. 1000 per 100,000 per year

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